Neurons have a high energy cost mainly sustained by glucose, but paradoxically present a weak glycolysis. This fact is now shown to account for healthy bioenergetics, reduced mitochondrial redox stress and whole-body fitness. Mice with high glycolytic rates in neurons present impaired autophagy, cognitive defects and metabolic-like syndrome.

中文翻译：

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神经元低糖酵解维持身体健康


神经元的能量消耗较高，主要由葡萄糖维持，但矛盾的是，糖酵解较弱。这一事实现在被证明可以解释健康的生物能量学、减少线粒体氧化还原应激和全身健康。神经元糖酵解率高的小鼠表现出自噬受损、认知缺陷和代谢样综合征。