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Early Infant Prefrontal Cortical Microstructure Predicts Present and Future Emotionality
Biological Psychiatry ( IF 9.6 ) Pub Date : 2024-04-09 , DOI: 10.1016/j.biopsych.2024.04.001
Yicheng Zhang 1 , Layla Banihashemi 2 , Amelia Versace 2 , Alyssa Samolyk 2 , Megan Taylor 2 , Gabrielle English 2 , Vanessa J Schmithorst 3 , Vincent K Lee 4 , Richelle Stiffler 2 , Haris Aslam 2 , Ashok Panigrahy 3 , Alison E Hipwell 2 , Mary L Phillips 2
Affiliation  

High levels of infant negative emotionality (NE) and low positive emotionality (PE) predict future emotional and behavioral problems. The prefrontal cortex (PFC) supports emotional regulation, with each PFC subregion specializing in specific emotional processes. Neurite orientation dispersion and density imaging estimates microstructural integrity and myelination via the neurite density index (NDI) and dispersion via the orientation dispersion index (ODI), with potential to more accurately evaluate microstructural alterations in the developing brain. Yet, no study has used these indices to examine associations between PFC microstructure and concurrent or developing infant emotionality.

中文翻译:


婴儿早期前额叶皮质微结构预测现在和未来的情绪



高水平的婴儿消极情绪 (NE) 和低水平的积极情绪 (PE) 预示着未来的情绪和行为问题。前额叶皮层 (PFC) 支持情绪调节,每个 PFC 子区域都专门用于特定的情绪过程。神经突取向色散和密度成像通过神经突密度指数 (NDI) 估计微观结构完整性和髓鞘形成,通过取向色散指数 (ODI) 估计色散,有可能更准确地评估发育中大脑的微观结构改变。然而,没有研究使用这些指数来检查 PFC 微观结构与并发或发展中的婴儿情绪之间的关联。
更新日期:2024-04-09
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