The objective of the current study was to investigate, for the first time, the association between individual-level residential greenspace and redemption of antidepressant drugs in a longitudinal nationwide population-based sample in Sweden. A nationwide population-based sample of adults residing in Sweden was studied during 2013–2016 (N = 108716; N = 324378). Residential greenspace land cover was assessed via high resolution geographic information systems, at 50, 100, 300, and 500 m buffers around individual residences. Antidepressant redemptions were assessed through the Swedish National Prescribed Drug Register. Greenspace-antidepressant associations were analyzed using generalized estimating equations (GEE), adjusting for demographic, socioeconomic and urban factors. Higher greenspace within 50–500 m residential buffer zones was associated with lower levels of prevalent antidepressant redemptions (50 m, odds ratio [OR] 0.878; 100 m, OR 0.891; 300 m, OR 0.873; 500 m, OR 0.899), while only greenspace in the 50 m buffer was associated with incident antidepressant redemptions (OR 0.853), in covariate-adjusted models. In conclusion, residential greenspace is associated with statistically significantly lower prevalent and incident antidepressant medication redemptions. The association is particularly salient for greenspace in the closest buffer zone around the residence. The results underscore the importance of green infrastructure and greenspace in the immediate residential-surrounding environment for mental health, and further point towards the need for an environmental psychiatry framework, and the importance of integrating health and environmental policies, urban planning and greening.

中文翻译：

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更多绿色，更少抑郁：一项基于全国人口的研究显示，住宅绿地与较低的抗抑郁药兑换率相关


本研究的目的是首次在瑞典全国范围内的纵向人口样本中调查个人住宅绿地与抗抑郁药物兑换之间的关联。 2013 年至 2016 年期间，对居住在瑞典的成年人进行了全国范围内的人口样本研究（N = 108716；N = 324378）。住宅绿地土地覆盖通过高分辨率地理信息系统在单个住宅周围 50、100、300 和 500 米缓冲区进行评估。抗抑郁药的兑换是通过瑞典国家处方药登记册进行评估的。使用广义估计方程（GEE）分析绿色空间与抗抑郁药的关联，并根据人口、社会经济和城市因素进行调整。 50-500 m 住宅缓冲区内绿地面积越大，抗抑郁药物的普遍使用率越低（50 m，比值比 [OR] 0.878；100 m，OR 0.891；300 m，OR 0.873；500 m，OR 0.899），而在协变量调整模型中，只有 50 m 缓冲区中的绿地与事件抗抑郁药兑换相关（OR 0.853）。总之，住宅绿地与统计上显着较低的流行和事件抗抑郁药物兑换相关。这种关联对于住宅周围最近的缓冲区内的绿地尤其重要。结果强调了居住周围环境中的绿色基础设施和绿色空间对心理健康的重要性，并进一步指出了环境精神病学框架的必要性，以及整合健康和环境政策、城市规划和绿化的重要性。