Traf2- and Nck-interacting kinase (TNIK) has emerged as a key regulator of pathological metabolic signaling in several diseases and is a promising drug target. Originally studied for its role in cell migration and proliferation, TNIK possesses several newly identified functions that drive the pathogenesis of multiple diseases. Specifically, we evaluate TNIK’s newfound roles in cancer, metabolic disorders, and neuronal function. We emphasize the implications of TNIK signaling in metabolic signaling and evaluate the translational potential of these discoveries. We also highlight how TNIK’s role in many biological processes converges upon several hallmarks of aging. We conclude by discussing the therapeutic landscape of TNIK-targeting drugs and the recent success of clinical trials targeting TNIK.

中文翻译：

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TNIK 在癌症、新陈代谢和年龄相关疾病中的新兴作用


Traf2 和 Nck 相互作用激酶 (TNIK) 已成为多种疾病病理代谢信号的关键调节因子，并且是一个有前途的药物靶点。 TNIK 最初是因其在细胞迁移和增殖中的作用而被研究，它具有多种新发现的功能，可驱动多种疾病的发病机制。具体来说，我们评估了 TNIK 在癌症、代谢紊乱和神经元功能中新发现的作用。我们强调 TNIK 信号在代谢信号中的影响，并评估这些发现的转化潜力。我们还强调了 TNIK 在许多生物过程中的作用如何与衰老的几个特征相一致。最后，我们讨论了 TNIK 靶向药物的治疗前景以及最近针对 TNIK 的临床试验的成功。