Most targeted cancer drugs inhibit the oncogenic signals to which cancer cells are addicted. We discuss here a counterintuitive approach to cancer therapy, which consists of deliberate overactivation of the oncogenic signals to overload the stress responses of cancer cells. We discuss why such overactivation of oncogenic signaling, combined with perturbation of the stress response pathways, can be potentially effective in killing cancer cells, aiming to inspire further discussion and consideration.

中文翻译：

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致癌信号传导过度激活作为潜在癌症治疗策略的案例

大多数靶向抗癌药物都会抑制癌细胞所依赖的致癌信号。我们在这里讨论一种违反直觉的癌症治疗方法，该方法包括故意过度激活致癌信号以使癌细胞的应激反应超载。我们讨论了为什么这种致癌信号的过度激活与应激反应途径的扰动相结合，可能有效地杀死癌细胞，旨在激发进一步的讨论和思考。