Organellophagy regulates cell death:A potential therapeutic target for inflammatory diseases,Journal of Advanced Research

当前位置： X-MOL 学术 › J. Adv. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Organellophagy regulates cell death:A potential therapeutic target for inflammatory diseases
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-05-11 , DOI: 10.1016/j.jare.2024.05.012
Yu Duan ₁ , Ren-Qi Yao ₂ , Hua Ling ₃ , Li-Yu Zheng ₄ , Qi Fan ₄ , Qiong Li ₃ , Lu Wang ₅ , Qi-Yuan Zhou ₆ , Le-Min Wu ₃ , Xin-Gui Dai ₃ , Yong-Ming Yao ₄

Affiliation

Background

Dysregulated alterations in organelle structure and function have a significant connection with cell death, as well as the occurrence and development of inflammatory diseases. Maintaining cell viability and inhibiting the release of inflammatory cytokines are essential measures to treat inflammatory diseases. Recently, many studies have showed that autophagy selectively targets dysfunctional organelles, thereby sustaining the functional stability of organelles, alleviating the release of multiple cytokines, and maintaining organismal homeostasis. Organellophagy dysfunction is critically engaged in different kinds of cell death and inflammatory diseases.

Aim of review

We summarized the current knowledge of organellophagy (e.g., mitophagy, reticulophagy, golgiphagy, lysophagy, pexophagy, nucleophagy, and ribophagy) and the underlying mechanisms by which organellophagy regulates cell death.

Key scientific concepts of review

We outlined the potential role of organellophagy in the modulation of cell fate during the inflammatory response to develop an intervention strategy for the organelle quality control in inflammatory diseases.

中文翻译：

细胞器自噬调控细胞死亡：炎症性疾病的潜在治疗靶点

背景

细胞器结构和功能的失调改变与细胞死亡以及炎症性疾病的发生和发展有显著关系。维持细胞活力和抑制炎性细胞因子的释放是治疗炎性疾病的重要措施。最近，许多研究表明，自噬选择性地靶向功能失调的细胞器，从而维持细胞器的功能稳定性，减轻多种细胞因子的释放，维持机体稳态。细胞器自噬功能障碍与不同类型的细胞死亡和炎症性疾病密切相关。