There is increasing interest in the use of omega-3 supplements to reduce aggressive behavior. This meta-analysis summarizes findings from 29 RCTs (randomized controlled trials) on omega-3 supplementation to reduce aggression, yielding 35 independent samples with a total of 3918 participants. Three analyses were conducted where the unit of analysis was independent samples, independent studies, and independent laboratories. Significant effect sizes were observed for all three analyses (g = 0.16, 0.20, 0.28 respectively), averaging 0.22, in the direction of omega-3 supplementation reducing aggression. There was no evidence of publication bias, and sensitivity analyses confirmed findings. Moderator analyses were largely non-significant, indicating that beneficial effects are obtained across age, gender, recruitment sample, diagnoses, treatment duration, and dosage. Omega-3 also reduced both reactive and proactive forms of aggression, particularly with respect to self-reports (g = 0.27 and 0.20 respectively). It is concluded that there is now sufficient evidence to begin to implement omega-3 supplementation to reduce aggression in children and adults - irrespective of whether the setting is the community, the clinic, or the criminal justice system.

中文翻译：

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补充 Omega-3 可减少攻击行为：随机对照试验的荟萃分析综述


人们越来越关注使用 omega-3 补充剂来减少攻击性行为。这项荟萃分析总结了 29 项关于补充 omega-3 以减少攻击性的 RCT（随机对照试验）的结果，产生了 35 个独立样本，共有 3918 名参与者。进行了三项分析，分析单位是独立样本、独立研究和独立实验室。所有三项分析均观察到显着的效应大小（g 分别为 0.16、0.20、0.28），平均为 0.22，表明补充 omega-3 可以减少攻击性。没有证据表明存在发表偏倚，敏感性分析证实了研究结果。调节分析基本上不显着，表明在年龄、性别、招募样本、诊断、治疗持续时间和剂量方面都获得了有益的影响。 Omega-3 还可以减少反应性和主动性攻击行为，特别是在自我报告方面（g 分别 = 0.27 和 0.20）。结论是，现在有足够的证据可以开始补充 omega-3，以减少儿童和成人的攻击性——无论环境是社区、诊所还是刑事司法系统。