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No pain, no gain — how nociceptors orchestrate tissue repair
Cell Research ( IF 28.1 ) Pub Date : 2024-05-23 , DOI: 10.1038/s41422-024-00979-4 Pavel Hanč 1, 2 , Ulrich H von Andrian 1, 2
中文翻译：
没有痛苦，就没有收获——伤害感受器如何协调组织修复
更新日期：2024-05-23
Cell Research ( IF 28.1 ) Pub Date : 2024-05-23 , DOI: 10.1038/s41422-024-00979-4 Pavel Hanč 1, 2 , Ulrich H von Andrian 1, 2
Affiliation
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Pain-sensing peripheral neurons, nociceptors, exert control over many aspects of the immune response through various means, including the secretion of immunomodulatory molecules. Adding to the growing list of such interactions, a recent article by Lu et al. reported that a nociceptive neuropeptide, calcitonin gene-related peptide, induces thrombospondin-1 expression in macrophages and neutrophils, limiting their pro-inflammatory functions and promoting tissue repair after injury.
中文翻译：
没有痛苦，就没有收获——伤害感受器如何协调组织修复
疼痛感知周围神经元（伤害感受器）通过各种方式（包括免疫调节分子的分泌）对免疫反应的许多方面进行控制。 Lu 等人最近发表的一篇文章增加了此类相互作用的不断增长的列表。据报道，一种伤害性神经肽——降钙素基因相关肽，可诱导巨噬细胞和中性粒细胞中血小板反应蛋白-1的表达，限制其促炎功能并促进损伤后的组织修复。
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