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Case of the month from the Radiotherapy Unit, Department of Medical and Surgical Sciences, University of Bologna, Italy: breaking boundaries beyond five lesions with multifocal stereotactic radiotherapy in prostate cancer
BJU International ( IF 3.7 ) Pub Date : 2024-05-22 , DOI: 10.1111/bju.16399
Erika Galietta 1, 2 , Silvia Strolin 3 , Elisa Lodi-Rizzini 2 , Paolo Castellucci 4 , Savino Cilla 5 , Milly Buwenge 1 , Maria Vadala' 4 , Stefano Fanti 1, 4 , Maria Ntreta 2 , Lidia Strigari 3 , Alessio G Morganti 1, 2
Affiliation  

Introduction

Stereotactic body radiotherapy (SBRT), characterised by its precise and focused delivery of high doses of radiation to well-defined targets, has emerged as an effective treatment modality for oligometastatic prostate cancer (PCa). Traditionally applied to patients with a limited number of metastases (≤5) [1], SBRT offers targeted therapeutic benefits. In this case study, we present an exceptional instance wherein a patient with PCa underwent SBRT for 20 metastatic lesions concurrently. This innovative approach served as a bridge therapy, strategically used in the interim as the patient awaited the availability of the prostate-specific membrane antigen (PSMA)-targeted radioligand therapy lutetium-177 (177Lu-PSMA-617) vipivotide tetraxetan.



中文翻译:


意大利博洛尼亚大学医学与外科科学系放射治疗科的本月病例:在前列腺癌中,使用多焦点立体定向放疗打破五个病灶以外的界限


 介绍


立体定向放射治疗 (SBRT) 的特点是将其高剂量辐射精确和集中地输送到明确的靶区,已成为寡转移性前列腺癌 (PCa) 的有效治疗方式。传统上,SBRT 适用于转移数量有限的患者 (≤5) [1],具有针对性的治疗益处。在本案例研究中,我们提出了一个特殊实例,其中一名 PCa 患者同时接受了 20 个转移病灶的 SBRT。这种创新方法作为一种过渡疗法,在患者等待前列腺特异性膜抗原 (PSMA) 靶向放射配体治疗镥 177 (177Lu-PSMA-617) vipivotide tetraxetan 的可用性时战略性地使用。

更新日期:2024-05-22
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