The role of high-mobility group box 1 (HMGB1) in the pathogenesis of febrile seizures (FSs) is unclear. In our controlled follow-up study, we compared serum levels of HMGB1 (s-HMGB1) in the same individuals after the first FS, during febrile episodes without a FS, after recurrent FS, during healthy periods after FS, and between patients and controls. In all, 122 patients with FSs were included in the final analysis, including 18 with recurrent FSs with a complete follow-up protocol. We recruited 30 febrile children and 18 matched febrile children without seizures as controls. S-HMGB1 was lower in patients with recurrent FSs after the first FS than that in matched febrile control children (median 1.12 μg/L (0.14–2.95) vs 1.79 μg/L (0.33–47.90), P<0.04). We did not find any other differences in s-HMGB1 between the groups. S-HMGB1 did not differ in different types of FSs. We updated a meta-analysis of s-HMGB1 in patients with FSs and found that the differences were significant only in the studies conducted in East Asian populations. We conclude that S-HMGB1 does not seem to be a key factor in the pathogenesis of FSs but differences in HMGB1 concentrations could explain some of the ethnicity related susceptibility to FSs.

中文翻译：

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热性惊厥血清 HMGB1


高迁移率族蛋白 1 (HMGB1) 在热性惊厥 (FS) 发病机制中的作用尚不清楚。在我们的对照随访研究中，我们比较了同一个体在首次 FS 后、无 FS 的发热发作期间、复发 FS 后、FS 后健康期间以及患者和对照组之间的 HMGB1 (s-HMGB1) 血清水平。最终分析总共纳入了 122 名 FS 患者，其中 18 名具有完整随访方案的复发性 FS 患者。我们招募了 30 名发热儿童和 18 名匹配的无癫痫发作的发热儿童作为对照。首次 FS 后复发 FS 的患者中 S-HMGB1 低于匹配的发热对照儿童（中位值 1.12 μg/L (0.14–2.95) vs 1.79 μg/L (0.33–47.90)，P<0.04）。我们没有发现各组之间 s-HMGB1 存在任何其他差异。 S-HMGB1在不同类型的FS中没有差异。我们更新了 FS 患者中 s-HMGB1 的荟萃分析，发现仅在东亚人群中进行的研究中差异才显着。我们的结论是，S-HMGB1 似乎并不是 FS 发病机制的关键因素，但 HMGB1 浓度的差异可以解释一些与 FS 相关的种族易感性。