Primary squamous cell carcinoma (SCC) of the thyroid and anaplastic thyroid carcinoma (ATC) show significant clinical and histologic overlap. Their biological behaviors are so similar that the fifth WHO updates SCC as a morphologic pattern of ATC rather than a separate entity. However, molecular genomic evidence that determines them as the same histologic type is limited. We aimed to explore whether they belong to the same classification from a molecular-typing perspective.

中文翻译：

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原发性甲状腺鳞状细胞癌具有与甲状腺未分化癌不同的分子遗传特征：全外显子组测序和基因表达谱研究。


甲状腺原发性鳞状细胞癌 (SCC) 和甲状腺未分化癌 (ATC) 显示出显着的临床和组织学重叠。它们的生物学行为非常相似，以至于第五次 WHO 将 SCC 更新为 ATC 的形态模式，而不是一个单独的实体。然而，将它们确定为相同组织学类型的分子基因组证据是有限的。我们的目的是从分子分型的角度探讨它们是否属于同一分类。