The good lubrication ability of articular cartilage holds significant importance in our daily lives. Osteoarthritis (OA), the most prevalent degenerative joint disease, causes cartilage damage, increased friction, and inflammation. However, the current clinical treatments for OA exhibit some defects. Recently, the sustained drug release systems with lubricating function have attracted considerable attention for treating OA. This review introduces the lubrication mechanism of cartilage, focusing particularly on the boundary lubrication mechanism. The research progress of boundary-lubricated biomaterials with drug delivery, including microcarriers, hydrogels, and nanoparticles in the treatment of OA by improving inter-articular lubrication and relieving inflammation is discussed and summarized. The efficacy and challenges of boundary-lubricated biomaterials with drug delivery in the treatment of OA are summarized, and the prospects are also discussed.

关节软骨良好的润滑能力在我们的日常生活中具有重要意义。骨关节炎 (OA) 是最常见的退行性关节疾病，会导致软骨损伤、摩擦增加和炎症。然而，目前临床上OA的治疗存在一些缺陷。近年来，具有润滑功能的药物缓释系统在治疗骨关节炎方面引起了广泛关注。本文介绍了软骨的润滑机制，特别关注边界润滑机制。讨论和总结了微载体、水凝胶和纳米粒子等边界润滑药物递送生物材料通过改善关节间润滑和缓解炎症来治疗骨关节炎的研究进展。总结了边界润滑生物材料在治疗 OA 中的疗效和挑战，并对其前景进行了讨论。