Direct C–H alkylation of 3,4-dihydroquinoxaline-2-ones with N-(acyloxy)phthalimides via radical–radical cross coupling,Chemical Communications

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Direct C–H alkylation of 3,4-dihydroquinoxaline-2-ones with N-(acyloxy)phthalimides via radical–radical cross coupling
Chemical Communications ( IF 4.3 ) Pub Date : 2024-05-23 , DOI: 10.1039/d4cc01837k
Sudhir Kumar Hota ₁ , Gulshan Singh ₁ , Sandip Murarka ₁

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We present an organophotoredox-catalyzed direct Csp³–H alkylation of 3,4-dihydroquinoxalin-2-ones employing N-(acyloxy)pthalimides to provide corresponding products in good yields. A broad spectrum of NHPI esters (1°, 2°, 3°, and sterically encumbered) participates in the photoinduced alkylation of a variety of 3,4-dihydroquinoxalin-2-ones. In general, mild conditions, broad scope with good functional group tolerance, and scalability are the salient features of this direct alkylation process.

中文翻译：

3,4-二氢喹喔啉-2-酮与N-(酰氧基)邻苯二甲酰亚胺通过自由基-自由基交叉偶联直接C-H烷基化

我们提出了一种有机光氧化还原催化的 3,4-二氢喹喔啉-2-酮的直接 Csp ³ -H 烷基化反应，采用N -(酰氧基)邻苯二甲酰亚胺，以良好的产率提供相应的产物。多种 NHPI 酯（1°、2°、3° 和空间阻碍）参与多种 3,4-二氢喹喔啉-2-酮的光诱导烷基化。总体而言，该直接烷基化工艺的显着特点是条件温和、适用范围广、官能团耐受性好、可扩展性好。

更新日期：2024-05-23

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