A sensitive sandwich-type electrochemical aptasensing platform based on Ti3C2Tx/MoS2/MWCNT@rGONR composites for simultaneous detection of kanamycin and chloramphenicol in food samples,Analytical Methods

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A sensitive sandwich-type electrochemical aptasensing platform based on Ti3C2Tx/MoS2/MWCNT@rGONR composites for simultaneous detection of kanamycin and chloramphenicol in food samples
Analytical Methods ( IF 2.7 ) Pub Date : 2024-05-20 , DOI: 10.1039/d4ay00545g
Xin Yao _{1,

2} , Liyu Yang _{1,

2} , Siyi Yang _{1,

2} , Jinhui Shen _{1,

2} , Danqun Huo _{1,

2} , Huanbao Fa ₃ , Changjun Hou _{1,

2} , Mei Yang _{1,

2}

Affiliation

A Ti₃C₂T_x/MoS₂/MWCNT@rGONR nanocomposite was prepared for the first time for building a sensitive electrochemical aptasening platform to simultaneously detect kanamycin (Kana) and chloramphenicol (Cap). Owing to their accordion-like structure, rich surface groups, and high charge mobility, Ti₃C₂T_x/MoS₂/MWCNT@rGONR composites provided a spacious covalent immobilization surface and a better electrochemical aptasensing platform. The aptamers of Kana and Cap used in sensors enhance the selectivity. Furthermore, TiP, an ion exchanger, was used for loading more different metal ions functioning as labels to form a sandwich-type sensor together with Ti₃C₂T_x/MoS₂/MWCNT@rGONR, improving the electrochemical sensitivity and obtaining a highly distinguishable signal readout. Under the optimized conditions, the sensor has good detection limits of 0.135 nmol L⁻¹ and 0.173 nmol L⁻¹ for Kana and Cap, respectively, at the same linearity concentration of 0.5–2500 nmol L⁻¹. Finally, it was successfully applied for detection in milk and fish meat, and the results were compared with the standard method HPLC, indicating its great potential for food safety monitoring.

中文翻译：

基于Ti3C2TX/MoS2/MWCNT@rGONR复合材料的灵敏夹心型电化学适体传感平台，用于同时检测食品样品中的卡那霉素和氯霉素

首次制备了Ti ₃ C ₂ T _x /MoS ₂ /MWCNT@rGONR纳米复合材料，用于构建同时检测卡那霉素（Kana）和氯霉素（Cap）的灵敏电化学适体平台。由于其手风琴状结构、丰富的表面基团和高电荷迁移率，Ti ₃ C ₂ T _x /MoS ₂ /MWCNT@rGONR 复合材料提供了宽敞的共价固定表面和更好的电化学适体传感平台。传感器中使用的 Kana 和 Cap 适体增强了选择性。此外，离子交换剂TiP被用来负载更多不同的金属离子作为标记，与Ti ₃ C ₂ T _x /MoS ₂ /MWCNT@rGONR一起形成夹心型传感器，提高了电化学灵敏度，获得了较高的电化学灵敏度。可区分的信号读数。在优化条件下，在0.5-2500 nmol L ^-1的相同线性浓度下，传感器对Kana和Cap分别具有良好的检测限，分别为0.135 nmol L ^-1和0.173 nmol L ^-1 。最后成功应用于牛奶和鱼肉中的检测，并将结果与标准方法HPLC进行比较，表明其在食品安全监测方面的巨大潜力。

更新日期：2024-05-20

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