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To slide or not to slide: key role of the hexasome in chromatin remodeling revealed
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2024-05-20 , DOI: 10.1038/s41594-024-01278-7 Daniela Rhodes 1
中文翻译：
滑动或不滑动：揭示六体在染色质重塑中的关键作用
更新日期：2024-05-21
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2024-05-20 , DOI: 10.1038/s41594-024-01278-7 Daniela Rhodes 1
Affiliation
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Hexasomes are non-canonical nucleosomes that package DNA with six instead of eight histones. First discovered 40 years ago as a consequence of transcription, two near-atomic-resolution cryo-EM structures of the hexasome in complex with the chromatin remodeler INO80 have now started to unravel its mechanistic impact on the regulatory landscape of chromatin. Loss of one histone H2A–H2B dimer converts inactive nucleosomes into distinct and favorable substrates for ATP-dependent chromatin remodeling.
中文翻译：
滑动或不滑动：揭示六体在染色质重塑中的关键作用
六体是非典型核小体，用六个而不是八个组蛋白包装 DNA。 40 年前首次发现，作为转录的结果，六体的两个近原子分辨率的冷冻电镜结构与染色质重塑剂 INO80 复合，现在已经开始揭示其对染色质调控景观的机制影响。失去一种组蛋白 H2A-H2B 二聚体会将无活性的核小体转化为 ATP 依赖性染色质重塑的独特且有利的底物。
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