By using genetic admixture in the multi-omic analysis of postmortem brains from Black Americans, we show that genetic ancestry influences gene expression in the brain. Notably, we find enrichment of ancestry-associated genes for immune response and vascular function, but not neuronal function. Our findings have potential implications for stroke, Parkinson’s disease and Alzheimer’s disease.

中文翻译：

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遗传血统有助于大脑中的基因表达


通过在美国黑人死后大脑的多组学分析中使用遗传混合物，我们表明遗传血统影响大脑中的基因表达。值得注意的是，我们发现免疫反应和血管功能的祖先相关基因富集，但神经元功能没有富集。我们的研究结果对中风、帕金森病和阿尔茨海默病具有潜在影响。