AimThis study aimed to compare microbial and inflammatory profiles in periodontally/systemically healthy African American (AA) and Caucasian (C) individuals.Materials and MethodsThirty‐seven C and 46 AA aged from 5 to 25 years were evaluated regarding periodontal disease, caries, microbial subgingival profile via 16‐s sequencing, as well as salivary and gingival crevicular fluid (GCF) inflammatory profile via multiplex assay.ResultsGreater probing depth percentage was detected in AA (p = .0075), while a higher percentage of caries index (p = .0069) and decayed, missing, filled teeth (DMFT) index (p = .0089) was observed in C, after adjusting for number of teeth, sex and age. Salivary levels of IL‐6, IL‐8 and TNFα were higher for C, whereas GCF levels of eotaxin, IL‐12p40, IL‐12p70, IL‐2 and MIP‐1α were higher in AA (p < .05). Different microbial profiles were observed between the races (p = .02). AA presented higher abundance of periodontopathogens (such as Tanerella forsythia, Treponema denticola, Filifactor alocis, among others), and C presented more caries‐associated bacteria (such as Streptococcus mutans and Prevotella species). Bacillaceae and Lactobacillus species were associated with higher DMFT index, whereas Fusobacterium and Tanerella species with periodontal disease parameters.ConclusionsA different inflammatory and bacterial profile was observed between healthy AA and C, which may predispose these races to higher susceptibility to specific oral diseases.

中文翻译：

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健康的年轻非裔美国人和高加索人的牙周炎和微生物特征


目的本研究旨在比较牙周病/全身健康的非裔美国人 （AA） 和高加索人 （C） 个体的微生物和炎症特征。材料和方法通过 16 秒测序评估 37 例 C 和 46 例 AA 年龄在 5 至 25 岁之间的牙周病、龋齿、微生物龈下特征，以及通过多重测定评估唾液和牙龈沟液 （GCF） 炎症特征。结果在调整牙齿数量、性别和年龄后，在 AA 中检测到更高的探诊深度百分比 （p = .0075），而在 C 中观察到较高的龋齿指数百分比 （p = .0069） 和蛀牙、缺失、补牙 （DMFT） 指数 （p = .0089）。C 的唾液中 IL-6、IL-8 和 TNFα 水平较高，而 AA 中嗜酸性粒细胞趋化因子、IL-12p40、IL-12p70、IL-2 和 MIP-1α 的 GCF 水平较高 （p < .05）。在种族之间观察到不同的微生物谱 （p = .02）。AA 呈现出更高丰度的牙周病原菌 （如连翘坦内拉菌、齿状螺旋体、Filifactor alocis 等），C 呈现更多的龋齿相关细菌 （如变形链球菌和普雷沃菌属）。芽孢杆菌科和乳酸菌属与较高的 DMFT 指数相关，而梭杆菌属和坦内拉菌属与牙周病参数相关。结论在健康的 AA 和 C 之间观察到不同的炎症和细菌特征，这可能使这些种族对特定口腔疾病的易感性更高。