ObjectiveTo determine the accuracy of salivary active matrix metalloproteinase (aMMP)‐8 point‐of‐care test (POCT) for detecting periodontitis in adults, through meta‐analysis.Materials and MethodsDiagnostic studies evaluating the accuracy of salivary/oral rinse aMMP‐8 POCT for detecting periodontitis in adults, when compared with clinical examination, were considered eligible. A comprehensive search was performed up to 31 August 2023 through five databases. Quality Assessment of Diagnostic Accuracy Studies 2 was utilized to evaluate the methodological quality of the included articles. Meta‐analysis was performed using Bayesian bivariate hierarchical model and subgroup analysis.ResultsFrom 368 screened studies, 6 studies (4 cross‐sectional and 2 longitudinal studies) were included in the meta‐analysis. Overall, the pooled sensitivity and specificity of salivary aMMP‐8‐POCT for detecting periodontitis were 0.63 (95% CI: 0.41–0.82) and 0.84 (95% CI: 0.65–0.95), respectively. Subgroup analyses revealed that the 95% CI for oral fluid types, predefined diagnostic thresholds and the POCT systems largely overlapped, indicating that the differences between them may not be significant.ConclusionSalivary aMMP‐8 POCT shows fair accuracy for detecting periodontitis. The diagnostic accuracy cannot be significantly influenced by the types of oral fluids, predefined diagnostic thresholds or the specific POCT systems used. More research is needed to confirm the clinical utility and implementation of aMMP‐8 POCT in the diagnosis of periodontitis.

中文翻译：

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唾液活性基质金属蛋白酶 （aMMP）-8 床旁检测检测成人牙周炎的诊断准确性：系统评价和荟萃分析


目的通过荟萃分析确定唾液活性基质金属蛋白酶 （aMMP）-8 床旁检测 （POCT） 检测成人牙周炎的准确性。材料和方法与临床检查相比，评估唾液/漱口水 aMMP-8 POCT 检测成人牙周炎准确性的诊断研究被认为符合条件。截至 2023 年 8 月 31 日，通过 5 个数据库进行了全面检索。诊断准确性研究质量评估 2 用于评估纳入文章的方法学质量。使用贝叶斯双变量分层模型和亚组分析进行 Meta 分析。结果从 368 项筛选研究中，6 项研究 （4 项横断面研究和 2 项纵向研究） 被纳入荟萃分析。总体而言，唾液 aMMP-8-POCT 检测牙周炎的合并敏感性和特异性分别为 0.63 （95% CI： 0.41-0.82） 和 0.84 （95% CI： 0.65-0.95）。亚组分析显示，口腔液类型、预定义诊断阈值和 POCT 系统的 95% CI 在很大程度上重叠，表明它们之间的差异可能不显著。结论唾液 aMMP-8 POCT 检测牙周炎的准确性相当。诊断准确性不会受到口腔液类型、预定义诊断阈值或使用的特定 POCT 系统的显著影响。需要更多的研究来证实 aMMP-8 POCT 在牙周炎诊断中的临床效用和实施。