Discovery of Photoexcited 2-Chloro-3,5-Dinitrobenzoic Acid as a Chemical Deprenylase of i6A RNA,ChemBioChem

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Discovery of Photoexcited 2-Chloro-3,5-Dinitrobenzoic Acid as a Chemical Deprenylase of i6A RNA
ChemBioChem ( IF 2.6 ) Pub Date : 2024-05-20 , DOI: 10.1002/cbic.202400361
Xin Sun _{1,

2} , Tian-He Hui ₃ , Li Liu _{1,

2} , Liang Cheng _{1,

2,

3}

Affiliation

Based on the efficient application of nitroaromatics in the chemical field, we have developed a novel reaction achieving direct deisopentenylation of i⁶A at the nucleotide level under blue light irradiation with high specific selectively and reaction efficiency. This method provided a photo-controlled intervention mode for the degradation of i⁶A. RNA modifications regulate gene expression and cellular homeostasis. Targeting RNA-modifying enzymes is a promising therapeutic strategy but faces challenges like unidentified enzymes and compensatory mechanisms. Chemical approaches offer alternatives. We have identified 2-chloro-3,5-dinitrobenzoic acid as an effective photochemical deprenylase of i⁶A RNA, converting it to natural adenine, advancing RNA modification biology and therapeutic development.

中文翻译：

发现光激发 2-氯-3,5-二硝基苯甲酸作为 i6A RNA 的化学去普瑞尼基酶

基于硝基芳烃在化学领域的高效应用，我们开发了一种在蓝光照射下实现i ⁶ A在核苷酸水平上直接脱异戊烯基化的新反应，具有高特异性选择性和反应效率。该方法为 i ⁶ A 的降解提供了光控干预模式。RNA 修饰调节基因表达和细胞稳态。以 RNA 修饰酶为靶点是一种很有前景的治疗策略，但面临着未知酶和补偿机制等挑战。化学方法提供了替代方案。我们已确定 2-氯-3,5-二硝基苯甲酸是 i ⁶ A RNA 的有效光化学去异戊二烯基酶，可将其转化为天然腺嘌呤，从而推进 RNA 修饰生物学和治疗开发。

更新日期：2024-05-20

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