Cancer cells perturb lipid metabolic pathways for a variety of pro-tumorigenic functions, and deregulated cellular metabolism is a hallmark of cancer cells. Although alterations in lipid metabolism in cancer cells have been appreciated for over 20 years, there are no FDA-approved cancer treatments that target lipid-related pathways. Recent advances pertaining to cancer cell fatty acid synthesis (FAS), desaturation, and uptake, microenvironmental and dietary lipids, and lipid metabolism of tumor-infiltrating immune cells have illuminated promising clinical applications for targeting lipid metabolism. This review highlights emerging pathways and targets for tumor lipid metabolism that may soon impact clinical treatment.

中文翻译：

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癌症治疗中脂质代谢的新兴靶点


癌细胞扰乱脂质代谢途径以实现多种促肿瘤功能，而细胞代谢失调是癌细胞的一个标志。尽管癌细胞中脂质代谢的改变20多年来一直受到人们的重视，但FDA还没有批准针对脂质相关途径的癌症治疗方法。有关癌细胞脂肪酸合成（FAS）、去饱和和摄取、微环境和膳食脂质以及肿瘤浸润免疫细胞的脂质代谢的最新进展已经阐明了针对脂质代谢的有前景的临床应用。这篇综述强调了可能很快影响临床治疗的肿瘤脂质代谢的新兴途径和靶点。