<br>高性能多巴胺基超分子生物胶粘剂,Macromolecular Rapid Communications

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高性能多巴胺基超分子生物胶粘剂
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2024-05-17 , DOI: 10.1002/marc.202400345
Maximilian J L Hagemann ₁ , Lewis Chadwick ₁ , Marcus J Drake ₂ , Darryl J Hill ₃ , Benjamin C Baker ₁ , Charl F J Faul ₁

Affiliation

伤口闭合或外科手术的需求通常通过缝合来满足。不幸的是，这些通常是侵入性的或容易受到污染的。手术胶粘剂提供了替代解决方案，这些胶粘剂可以在不造成重大干扰的情况下进行应用和凝固;一类新型的超分子基胶粘剂为其中一些挑战提供了潜在的解决方案。在这项研究中，合成了一系列利用多巴胺作为自组装单元的聚合物。研究发现，这些基序充当极其有效的粘合剂，通过改变单体进料比例和交联水平来控制粘合的机械强度和材料的拉伸性能。这些材料的性能明显优于市售的生物胶粘剂，粘附后的屈服强度至少比 BioGlue 和 Tisseel 高两倍，并且能够重新粘附，粘合强度显著恢复。令人鼓舞的是，这些材料被证明是无细胞毒性的，细胞活力 > 为 90%，并且能够在水性环境中发挥作用而不会显着损失强度。最后，可以使用良性有机溶剂（如乙醇）去除材料。这些特性都证明了这些材料作为潜在生物粘合剂的有效性，在手术中具有潜在优势。

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High-Performance Dopamine-Based Supramolecular Bio-Adhesives

The need for wound closure or surgical procedures has been commonly met by the application of sutures. Unfortunately, these are often invasive or subject to contamination. Alternative solutions are offered by surgical adhesives that can be applied and set without major disruption; a new class of supramolecular-based adhesives provides potential solutions to some of these challenges. In this study, a series of polymers utilizing dopamine as a self-assembling unit are synthesized. It is found that these motifs act as extremely effective adhesives, with control over the mechanical strength of the adhesion and materials’ tensile properties enabled by changing monomer feed ratios and levels of cross-linking. These materials significantly outperform commercially available bio-adhesives, showing yield strengths after adhesion at least two times higher than that of BioGlue and Tisseel, as well as the ability to re-adhere with significant recovery of adhesion strength. Promisingly, the materials are shown to be non-cytotoxic, with cell viability > 90%, and able to perform in aqueous environments without significant loss in strength. Finally, the removal of the materials, is possible using benign organic solvents such as ethanol. These properties all demonstrate the effectiveness of the materials as potential bio-adhesives, with potential advantages for use in surgery.

更新日期：2024-05-17

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