Preparation of hollow double-layer Pt@CeO2 nanospheres as oxidase mimetics for the colorimetric-fluorescent-SERS triple-mode detection of glutathione in serum,Talanta

当前位置： X-MOL 学术 › Talanta › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Preparation of hollow double-layer Pt@CeO2 nanospheres as oxidase mimetics for the colorimetric-fluorescent-SERS triple-mode detection of glutathione in serum
Talanta ( IF 5.6 ) Pub Date : 2024-05-14 , DOI: 10.1016/j.talanta.2024.126234
Yiquan Liao ₁ , Yichang He ₁ , Bin Zhang ₁ , Ye Ma ₁ , Minggang Zhao ₁ , Ruiqi Xu ₁ , Hongzhi Cui ₁

Affiliation

Glutathione (GSH) is an essential antioxidant in the human body, but its detection is difficult due to the interference of complex components in serum. Herein, hollow double-layer Pt@CeO nanospheres were developed as oxidase mimetics, and the light-assisted oxidase mimetics effects were found. The oxidase activity was enhanced significantly by utilizing the synergistic effect of Schottky junction and the localized surface plasmon resonance (LSPR) of Pt under UV light. A novel GSH colorimetric-fluorescent-SERS sensing platform was established, with the sensing performance notably boosted by using the light-assisted oxidase mimetics effects. This platform boasts an exceptionally low detection limit (LOD) of 0.084 μM, while the detection time was shortened from 10 min to just 2 min. The anti-interference detection with high recovery rate (96.84%–107.4 %) in real serum made it be promising for practical application.

中文翻译：

制备空心双层 Pt@CeO2 纳米球作为氧化酶模拟物，用于血清中谷胱甘肽的比色-荧光-SERS 三模式检测

谷胱甘肽（GSH）是人体必需的抗氧化剂，但由于血清中成分复杂的干扰，检测难度较大。在此，开发了空心双层Pt@CeO纳米球作为氧化酶模拟物，并发现了光辅助氧化酶模拟效应。利用肖特基结和紫外光下 Pt 局域表面等离子共振 (LSPR) 的协同作用，氧化酶活性显着增强。建立了一种新型的 GSH 比色荧光 SERS 传感平台，利用光辅助氧化酶模拟效应显着提高了传感性能。该平台具有0.084 μM的极低检测限（LOD），同时检测时间从10分钟缩短至仅2分钟。真实血清中的抗干扰检测和高回收率（96.84%~107.4%）使其具有实际应用前景。

更新日期：2024-05-14

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南