Hydrogels have been used in the clinic since the late 1980s with broad applications in drug delivery, cosmetics, tissue regeneration, among many other areas. The past three decades have witnessed rapid advances in the fields of polymer chemistry, crosslinking approaches, and hydrogel fabrication methods, which have collectively brought many new hydrogel products, either injectable or non‐injectable, to clinical studies. In an article published in 2020 entitled “Hydrogels in the clinic”, we reviewed the clinical landscape and translational challenges of injectable hydrogels. Here, we provide an update on the advances in the field and also extend the scope to include non‐injectable hydrogels. We highlight recently approved hydrogel products, provide an update on the clinical trials of injectable hydrogels, and discuss active clinical trials of topically applied and implantable hydrogels.

中文翻译：

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水凝胶在临床中的应用：最新进展


自 1980 年代后期以来，水凝胶一直用于临床，广泛应用于药物输送、化妆品、组织再生以及许多其他领域。在过去的三十年里，聚合物化学、交联方法和水凝胶制造方法领域取得了快速发展，这些共同为临床研究带来了许多新的水凝胶产品，无论是注射的还是非注射的。在 2020 年发表的一篇题为“临床中的水凝胶”的文章中，我们回顾了可注射水凝胶的临床前景和转化挑战。在这里，我们提供了该领域的最新进展，并将范围扩展到包括非注射水凝胶。我们重点介绍了最近批准的水凝胶产品，提供了可注射水凝胶临床试验的最新情况，并讨论了局部应用和植入式水凝胶的积极临床试验。