Hydrogels have been used in the clinic since the late 1980s with broad applications in drug delivery, cosmetics, tissue regeneration, among many other areas. The past three decades have witnessed rapid advances in the fields of polymer chemistry, crosslinking approaches, and hydrogel fabrication methods, which have collectively brought many new hydrogel products, either injectable or non‐injectable, to clinical studies. In an article published in 2020 entitled “Hydrogels in the clinic”, we reviewed the clinical landscape and translational challenges of injectable hydrogels. Here, we provide an update on the advances in the field and also extend the scope to include non‐injectable hydrogels. We highlight recently approved hydrogel products, provide an update on the clinical trials of injectable hydrogels, and discuss active clinical trials of topically applied and implantable hydrogels.

中文翻译：

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诊所中的水凝胶：更新


水凝胶自 20 世纪 80 年代末以来一直用于临床，在药物输送、化妆品、组织再生等许多领域有着广泛的应用。过去三十年见证了聚合物化学、交联方法和水凝胶制造方法领域的快速发展，这些领域共同将许多新的水凝胶产品（无论是可注射的还是不可注射的）带入临床研究。在 2020 年发表的题为“临床中的水凝胶”的文章中，我们回顾了可注射水凝胶的临床前景和转化挑战。在这里，我们提供了该领域的最新进展，并将范围扩大到包括非注射水凝胶。我们重点介绍最近批准的水凝胶产品，提供可注射水凝胶临床试验的最新信息，并讨论局部应用和可植入水凝胶的活跃临床试验。