Despite the immense clinical success of the antibody therapeutics that neutralize programmed death receptor ligand 1 (PD-L1) and thus resurrect T cell antitumor activity, the patient response rates remain low. In this issue of Cell Chemical Biology, Ludwig et al.¹ reveal novel topologies of multiparatopic antibodies that mediate potent PD-L1 downregulation.

中文翻译：

---

鲨鱼为有效的抗肿瘤多互补位抗体提供了手段，诱导膜上的 PD-L1 耗竭

尽管中和程序性死亡受体配体 1 (PD-L1) 从而恢复 T 细胞抗肿瘤活性的抗体疗法在临床上取得了巨大成功，但患者的反应率仍然很低。在本期《细胞化学生物学》中，Ludwig 等人。^{图 1}揭示了介导强效 PD-L1 下调的多互补位抗体的新颖拓扑。