Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: Implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively,Drug Resistance Updates

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Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: Implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively
Drug Resistance Updates ( IF 15.8 ) Pub Date : 2024-04-26 , DOI: 10.1016/j.drup.2024.101088
Yating Guo ₁ , Geng Zou ₁ , Anusak Kerdsin ₂ , Constance Schultsz ₃ , Can Hu ₁ , Weicheng Bei ₁ , Huanchun Chen ₄ , Jinquan Li ₅ , Yang Zhou ₆

Affiliation

National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Key Laboratory of Environment Correlative Dietology, College of Biomedicine and Health, College of Fisheries, Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Wuhan 430070, China; Hubei Hongshan Laboratory, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Faculty of Public Health, Kasetsart University, Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand.
Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam 1100, the Netherlands; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam 1100, the Netherlands.
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Key Laboratory of Environment Correlative Dietology, College of Biomedicine and Health, College of Fisheries, Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Wuhan 430070, China.
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Key Laboratory of Environment Correlative Dietology, College of Biomedicine and Health, College of Fisheries, Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Wuhan 430070, China; Hubei Hongshan Laboratory, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200025, China.
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Key Laboratory of Environment Correlative Dietology, College of Biomedicine and Health, College of Fisheries, Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Wuhan 430070, China; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.

In this study, the progenitors of MCR-3, MCR-7 and MCR-5, namely NMCR-3, NMCR-4 and NMCR-5, were firstly discovered and indicating was a natural reservoir for MCR-3 and MCR-7. Furthermore, different evolutionary models for MCR-3, MCR-7 and MCR-5 were proposed.

中文翻译：

NMCR-3、NMCR-4 和 NMCR-5（三种新型非移动粘菌素耐药决定因素）的表征：分别对 MCR-3、MCR-7 和 MCR-5 祖细胞的影响

本研究首次发现了MCR-3、MCR-7和MCR-5的祖细胞NMCR-3、NMCR-4和NMCR-5，表明MCR-3和MCR-7是天然的储存库。此外，还提出了MCR-3、MCR-7和MCR-5的不同进化模型。

更新日期：2024-04-26

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