The management of antiphospholipid syndrome is hindered by heterogeneous clinical presentations. Whole-blood transcriptomics have the potential to identify previously unknown disease endotypes, which could inform new treatment strategies. However, such hypothesis-generating data must still account for the results of randomized clinical trials, such as those focused on direct oral anticoagulants in APS.

中文翻译：

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转录组学可以指导 SLE 相关 APS 的治疗吗？


不同的临床表现阻碍了抗磷脂综合征的治疗。全血转录组学有可能识别以前未知的疾病内型，这可以为新的治疗策略提供信息。然而，此类假设生成数据仍必须考虑随机临床试验的结果，例如针对 APS 中直接口服抗凝剂的试验。