Kong et al. have now shown that Knudson’s two-hit hypothesis can be circumvented through the actions of the glycolytic metabolite methylglyoxal, which transiently inactivates the tumour-suppressive functions of BRCA2 leading to episodic mutagenesis and cancer genome evolution.

中文翻译：

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 绕道而行


孔等人。现在已经表明，Knudson 的两次打击假说可以通过糖酵解代谢物甲基乙二醛的作用来规避，甲基乙二醛会暂时使 BRCA2 的肿瘤抑制功能失活，从而导致偶发性突变和癌症基因组进化。