Kong et al. have now shown that Knudson’s two-hit hypothesis can be circumvented through the actions of the glycolytic metabolite methylglyoxal, which transiently inactivates the tumour-suppressive functions of BRCA2 leading to episodic mutagenesis and cancer genome evolution.

中文翻译：

---

 绕道而行


Kong 等人现在已经表明，Knudson 的二击假说可以通过糖酵解代谢物甲基乙二醛的作用来规避，甲基乙二醛会暂时灭活 BRCA2 的肿瘤抑制功能，导致发作性诱变和癌症基因组进化。