Molecular probes for super-resolution imaging of drug dynamics,Advanced Drug Delivery Reviews

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Molecular probes for super-resolution imaging of drug dynamics
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-05-10 , DOI: 10.1016/j.addr.2024.115330
Hongbao Fang ₁ , Mengmeng Wang ₂ , Pengfan Wei ₃ , Qian Liu ₃ , Yan Su ₃ , Hongke Liu ₃ , Yuncong Chen ₄ , Zhi Su ₃ , Weijiang He ₅

Affiliation

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; College of Life Science and Chemistry, Jiangsu Key Laboratory of Biological Functional Molecules, Jiangsu Second Normal University, Nanjing, Jiangsu 210013, China.
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China; Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210008, PR China.
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.

Super-resolution molecular probes (SRMPs) are essential tools for visualizing drug dynamics within cells, transcending the resolution limits of conventional microscopy. In this review, we provide an overview of the principles and design strategies of SRMPs, emphasizing their role in accurately tracking drug molecules. By illuminating the intricate processes of drug distribution, diffusion, uptake, and metabolism at a subcellular and molecular level, SRMPs offer crucial insights into therapeutic interventions. Additionally, we explore the practical applications of super-resolution imaging in disease treatment, highlighting the significance of SRMPs in advancing our understanding of drug action. Finally, we discuss future perspectives, envisioning potential advancements and innovations in this field. Overall, this review serves to inform and practitioners about the utility of SRMPs in driving innovation and progress in pharmacology, providing valuable insights for drug development and optimization.

中文翻译：

用于药物动力学超分辨率成像的分子探针

超分辨率分子探针 (SRMP) 是可视化细胞内药物动力学的重要工具，超越了传统显微镜的分辨率限制。在这篇综述中，我们概述了 SRMP 的原理和设计策略，强调了它们在准确跟踪药物分子方面的作用。通过在亚细胞和分子水平阐明药物分布、扩散、摄取和代谢的复杂过程，SRMP 为治疗干预提供了重要的见解。此外，我们还探索了超分辨率成像在疾病治疗中的实际应用，强调了 SRMP 在增进我们对药物作用的理解方面的重要性。最后，我们讨论未来的前景，展望该领域的潜在进步和创新。总体而言，本次综述旨在向从业者介绍 SRMP 在推动药理学创新和进步方面的效用，为药物开发和优化提供宝贵的见解。

更新日期：2024-05-10

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