Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease,Advanced Drug Delivery Reviews

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Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-04-26 , DOI: 10.1016/j.addr.2024.115321
Maria João Faria ₁ , José M González-Méijome ₂ , M Elisabete C D Real Oliveira ₁ , Gonzalo Carracedo ₃ , Marlene Lúcio ₄

Affiliation

Posterior eye disorders, such as age-related macular degeneration, diabetic retinopathy, and glaucoma, have a significant impact on human quality of life and are the primary cause of age-related retinal diseases among adults. There is a pressing need for innovative topical approaches to treat posterior eye disorders, as current methods often rely on invasive procedures with inherent risks. Limited success was attained in the realm of topical ophthalmic delivery through non-invasive means. Additionally, there exists a dearth of literature that delves into the potential of this approach for drug delivery and theranostic purposes, or that offers comprehensive design strategies for nanocarrier developers to surmount the significant physiological ocular barriers.

中文翻译：

纳米载体介导的眼后部疾病局部治疗和治疗诊断的最新进展和策略

后眼部疾病，例如年龄相关性黄斑变性、糖尿病性视网膜病变和青光眼，对人类的生活质量具有重大影响，并且是成人年龄相关性视网膜疾病的主要原因。迫切需要创新的局部方法来治疗眼后部疾病，因为当前的方法通常依赖于具有固有风险的侵入性手术。通过非侵入性方式在局部眼科给药领域取得的成功有限。此外，还缺乏深入研究这种方法在药物输送和治疗诊断方面的潜力的文献，或者为纳米载体开发人员提供全面的设计策略以克服重要的生理性眼部障碍的文献。

更新日期：2024-04-26

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