The underlying mechanisms between polycyclic aromatic hydrocarbons (PAHs) exposure and arterial stiffness are poorly understood. We carried out a panel study involving three repeated surveys to examine the associations of individual and mixture of PAHs exposure with arterial stiffness-related miRNAs among 123 community adults. In linear mixed-effect (LME) models, we found that urinary 9-hydroxyfluorene (9-OHFlu), 2-hydroxyphenanthrene (2-OHPh), 9-hydroxyphenanthrene (9-OHPh) at lag 0 day were positively linked to miR-146a and/or miR-222. The Bayesian kernel machine regression (BKMR) analyses revealed positive overall associations of PAHs mixture at lag 0 day with miR-146a and miR-222, and urinary 9-OHFlu contributed the most. In addition, an inter-quartile range (IQR) increase in urinary 9-OHFlu at lag 0 day was associated with elevated miR-146a and miR-222 by 0.16 (95% CI: 0.02, 0.30) to 0.34 (95% CI: 0.13, 0.54). Accordingly, exposure to PAHs, especially 9-OHFlu at lag 0 day, was related to elevated arterial stiffness-related plasma miRNAs.

中文翻译：

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多环芳烃暴露和动脉僵硬度相关血浆 miRNA：一项小组研究


人们对多环芳烃 (PAH) 暴露与动脉僵硬度之间的潜在机制知之甚少。我们开展了一项小组研究，涉及三项重复调查，以检查 123 名社区成年人中个人和多环芳烃混合物暴露与动脉僵硬度相关 miRNA 的关联。在线性混合效应 (LME) 模型中，我们发现滞后 0 天时尿液中的 9-羟基芴 (9-OHFlu)、2-羟基菲 (2-OHPh)、9-羟基菲 (9-OHPh) 与 miR- 146a和/或miR-222。贝叶斯核机器回归 (BKMR) 分析显示，滞后 0 天时 PAH 混合物与 miR-146a 和 miR-222 总体呈正相关，其中尿液 9-OHFlu 贡献最大。此外，滞后 0 天时尿 9-OHFlu 的四分位数范围 (IQR) 增加与 miR-146a 和 miR-222 升高相关，升高 0.16 (95% CI: 0.02, 0.30) 至 0.34 (95% CI: 0.13、0.54）。因此，暴露于 PAH，尤其是滞后 0 天的 9-OHFlu，与动脉僵硬度相关血浆 miRNA 升高有关。