Background and HypothesisThis review examines the evolution and future prospects of prevention based on evaluation (PBE) for individuals at clinical high risk (CHR) of psychosis, drawing insights from the SHARP (Shanghai At Risk for Psychosis) study. It aims to assess the effectiveness of non-pharmacological interventions in preventing psychosis onset among CHR individuals.Study DesignThe review provides an overview of the developmental history of the SHARP study and its contributions to understanding the needs of CHR individuals. It explores the limitations of traditional antipsychotic approaches and introduces PBE as a promising framework for intervention.Study ResultsThree key interventions implemented by the SHARP team are discussed: nutritional supplementation based on niacin skin response blunting, precision transcranial magnetic stimulation targeting cognitive and brain functional abnormalities, and cognitive behavioral therapy for psychotic symptoms addressing symptomatology and impaired insight characteristics. Each intervention is evaluated within the context of PBE, emphasizing the potential for tailored approaches to CHR individuals.ConclusionsThe review highlights the strengths and clinical applications of the discussed interventions, underscoring their potential to revolutionize preventive care for CHR individuals. It also provides insights into future directions for PBE in CHR populations, including efforts to expand evaluation techniques and enhance precision in interventions.

中文翻译：

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基于临床精神病高危个体评估的预防进展和未来方向：来自 SHARP 研究的见解


背景和假设本综述研究了基于评估 （PBE） 的预防的演变和未来前景，针对精神病临床高危 （CHR） 个体，借鉴了 SHARP （上海精神病风险） 研究的见解。它旨在评估非药物干预在预防 CHR 个体精神病发作方面的有效性。研究设计本综述概述了 SHARP 研究的发展历史及其对了解 CHR 个体需求的贡献。它探讨了传统抗精神病药物方法的局限性，并介绍了 PBE 作为一种有前途的干预框架。研究结果讨论了 SHARP 团队实施的三种关键干预措施：基于烟酸皮肤反应减弱的营养补充剂，针对认知和大脑功能异常的精确经颅磁刺激，以及针对症状和洞察力受损特征的精神病症状的认知行为疗法。每项干预措施都在 PBE 的背景下进行评估，强调为 CHR 个体量身定制方法的潜力。结论该综述强调了所讨论的干预措施的优势和临床应用，强调了它们彻底改变 CHR 个体预防保健的潜力。它还提供了对 CHR 人群中 PBE 未来方向的见解，包括扩大评估技术和提高干预精度的努力。