ATP6AP1 was Phast-ID’ed as a long-sought GEF for Rheb,Cell Research

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ATP6AP1 was Phast-ID’ed as a long-sought GEF for Rheb
Cell Research ( IF 28.1 ) Pub Date : 2024-05-14 , DOI: 10.1038/s41422-024-00967-8
Song Li ₁ , Xinxing Ouyang _{1,

2} , Bing Su _{1,

3,

4}

Affiliation

A new study from Feng et al. developed an improved proximity labeling technology called PhastID and successfully identified the lysosomal v-ATPase subunit ATP6AP1 as an unconventional guanine nucleotide exchange factor for Rheb, a key positive regulator of mTORC1. ATP6AP1 binds directly to Rheb via a highly conserved C-terminal segment to promote its GTP loading and mTORC1 activation.

中文翻译：

ATP6AP1 已被 Phast-ID 鉴定为 Rheb 长期寻求的 GEF

冯等人的一项新研究。开发了一种改进的邻近标记技术，称为 PhastID，并成功鉴定了溶酶体 v-ATP 酶亚基 ATP6AP1 作为 Rheb 的非常规鸟嘌呤核苷酸交换因子，Rheb 是 mTORC1 的关键正调节因子。 ATP6AP1 通过高度保守的 C 端片段直接与 Rheb 结合，促进其 GTP 负载和 mTORC1 激活。

更新日期：2024-05-14

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