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IS607 TnpB is a hypercompact RNA-guided DNA endonuclease
Cell Research ( IF 28.1 ) Pub Date : 2024-05-14 , DOI: 10.1038/s41422-024-00973-w Hui Yang 1 , Dinshaw J Patel 2
中文翻译：
IS607 TnpB 是一种超紧凑 RNA 引导的 DNA 核酸内切酶
更新日期：2024-05-14
Cell Research ( IF 28.1 ) Pub Date : 2024-05-14 , DOI: 10.1038/s41422-024-00973-w Hui Yang 1 , Dinshaw J Patel 2
Affiliation
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The Zhiwei Huang lab report on a hypercompact IS607 TnpB protein that naturally co-occurs with the conserved RAGATH-18 RNA, thereby identifying a new family of compact RNA-guided DNA endonucleases. Such an IS607 TnpB-based approach for programmable genome editing in both Escherichia coli and human cells, combined with its structural and target-adjacent motif divergence from earlier reported IS200/IS605 TnpB systems, highlights the diversity of the non-Cas genome editor toolbox.
中文翻译：
IS607 TnpB 是一种超紧凑 RNA 引导的 DNA 核酸内切酶
黄志伟实验室报告了一种超紧凑的 IS607 TnpB 蛋白，该蛋白与保守的 RAGATH-18 RNA 自然共存，从而鉴定了一个新的紧凑 RNA 引导的 DNA 核酸内切酶家族。这种基于IS607 TnpB的方法在大肠杆菌和人类细胞中进行可编程基因组编辑，结合其与早期报道的IS200/IS605 TnpB系统的结构和靶标相邻基序的差异，凸显了非Cas基因组编辑工具箱的多样性。
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