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Piecing together aminergic polypharmacology
Cell Research ( IF 28.1 ) Pub Date : 2024-05-13 , DOI: 10.1038/s41422-024-00970-z Blake A Fordyce 1 , Bryan L Roth 1
中文翻译：
拼凑胺能多药理学
更新日期：2024-05-13
Cell Research ( IF 28.1 ) Pub Date : 2024-05-13 , DOI: 10.1038/s41422-024-00970-z Blake A Fordyce 1 , Bryan L Roth 1
Affiliation
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Neuropsychiatric medications are often designed to have affinity for multiple ligand-binding sites across different receptor types to increase therapeutic efficacy. In a recent paper in Cell, Chen and colleagues implement a flexible scaffold-based cheminformatics approach to design bi-target therapeutics for dementia-related psychosis.
中文翻译：
拼凑胺能多药理学
神经精神药物通常被设计为对不同受体类型的多个配体结合位点具有亲和力，以提高治疗效果。在最近发表在《细胞》杂志上的一篇论文中，陈和同事实施了一种灵活的基于支架的化学信息学方法来设计痴呆相关精神病的双靶疗法。
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