<br>用于高效润滑、ROS清除和骨关节炎治疗的新型仿生大分子系统,Colloids and Surfaces B: Biointerfaces

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用于高效润滑、ROS清除和骨关节炎治疗的新型仿生大分子系统
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2024-05-08 , DOI: 10.1016/j.colsurfb.2024.113956
Xiaoduo Zhao ₁ , Lumin Yang ₂ , Licheng Zhang ₃ , Le Ji ₄ , Shuanhong Ma ₁ , Feng Zhou ₂

Affiliation

关节骨关节炎（OA）的早期阶段通常有两个关键因素：关节软骨润滑功能障碍和活性氧（ROS）过量产生引起的炎症。合成的可注射高分子材料在预防早期骨关节炎的进展方面具有巨大的潜力。在这项研究中，为了模仿天然滑液中发现的刷状聚集体的优异润滑性，我们通过将粘附和水合基团整合到天然生物大分子的主链上，开发了一种新型大分子生物润滑剂（CS-PS-DA）。 CS-PS-DA对软骨表面具有很强的亲和力，能够在退化软骨的滑动界面上形成稳定的润滑层，从而恢复关节润滑性能。 ROS 清除和抗炎实验的结果表明，CS-PS-DA 在通过抑制 ROS 过量产生来降低促炎细胞因子水平方面具有巨大优势。最后，大鼠OA模型表明腔内注射CS-PS-DA可以有效抵抗软骨磨损并减轻关节炎症。这种新型生物润滑剂为骨关节炎的治疗提供了一种新的、及时的策略。

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Novel biomimetic macromolecules system for highly efficient lubrication, ROS scavenging and osteoarthritis treatment

The early stages of osteoarthritis (OA) in the joints are typically characterized by two key factors: the dysfunction of articular cartilage lubrication and inflammation resulting from the excessive production of reactive oxygen species (ROS). Synthetic injectable macromolecular materials present great potential for preventing the progression of early OA. In this study, to mimic the excellent lubricity of brush-like aggregates found in natural synovial fluid, we develop a novel macromolecular biolubricant (CS-PS-DA) by integrating adhesion and hydration groups onto backbone of natural biomacromolecules. CS-PS-DA exhibits a strong affinity for cartilage surfaces, enabling the formation of a stable lubrication layer at the sliding interface of degraded cartilages to restore joint lubrication performance. results from ROS scavenging and anti-inflammatory experiments indicate the great advantage of CS-PS-DA to decrease the levels of proinflammatory cytokines by inhibiting ROS overproduction. Finally, rats OA model demonstrates that intra-cavitary injection of CS-PS-DA could effectively resist cartilage wear and mitigated inflammation in the joints. This novel biolubricant provides a new and timely strategy for the treatment of OA.

更新日期：2024-05-08

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