<br>新型芳基硫代酰胺衍生物作为昆虫生长调节剂类似物对抗斜纹夜蛾（鳞翅目：夜蛾科）：设计、合成、杀虫活性和生化影响,Chemistry & Biodiversity

当前位置： X-MOL 学术 › Chem. Biodivers. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

新型芳基硫代酰胺衍生物作为昆虫生长调节剂类似物对抗斜纹夜蛾（鳞翅目：夜蛾科）：设计、合成、杀虫活性和生化影响
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2024-05-11 , DOI: 10.1002/cbdv.202400776
Badriah M K Asiri ₁

Affiliation

开发创新杀虫活性剂的一个重要原因是对传统化学农药的抗性呈指数级上升。探索具有不同作用机制的新型杀虫化合物是解决这一难题的一种方法。因此，通过芳酰氯、硫氰酸铵和芳香胺在干燥丙酮中的一锅三组分反应合成了新型芳基硫代酰胺衍生物3-15 。新合成的化合物的结构通过元素分析、 ¹ H-NMR、 ¹³ C NMR和红外光谱等多种光谱方法进行了验证。在实验室条件下，合成的化合物对滨夜蛾表现出良好的广谱杀虫活性。与其他合成目标化合物相比，2,4-二氯-N -[(3-氟苯基)硫氨甲酰]苯甲酰胺11、2,4-二氯-N -[(3-氟苯基)硫氨甲酰]苯硫甲酰胺13表现出良好的杀虫活性， 2^龄幼虫的 LC 50 值为 46.33 mg/L，LC ₅₀值为 49.25 mg/L。此外，化合物3在控制番茄叶上的北滨夜蛾二龄和四龄幼虫方面的毒性最小。此外，还检查了实验室环境下一些合成化合物的一些组织病理学和生化特征。

"点击查看英文标题和摘要"

Novel Aryl Thioamides Derivatives as Insect Growth Regulators Analogues against Spodoptera littoralis (Lepidoptera: Noctuidae): Design, Synthesis, Insecticidal Activity and Biochemical Impacts

A significant reason for developing innovative insecticidal active agents is the exponential rise in resistance to traditional chemical pesticides. Exploring new classes of insecticidal compounds with distinct mechanisms of action is one way to address this difficulty. So that, novel aryl thioamides derivatives 3–15 has been synthesized viaone-pot, three-component reaction of aroyl chloride, ammonium thiocyanate, and aromatic amines in dry acetone. The newly synthesized compounds′ structures were validated by various spectroscopic methods, including elemental analysis, ¹H-NMR, ¹³C NMR, and infrared spectroscopy. Under laboratory circumstances, the synthesized compounds showed good and broad-spectrum insecticidal activities toward S. littorali. When compared to other synthetic target compounds, 2,4-dichloro-N-[(3-fluorophenyl)carbamothioyl]benzamide 11, 2,4-dichloro-N-[(3-fluorophenyl)carbamothioyl]benzenecarbothioamide 13 showed good insecticidal activity, with 46.33 mg/L and LC₅₀ values of 49.25 mg/L for 2^nd instar larvae. Furthermore, the compound 3 was the least toxic in controlling the second and fourth instar larvae of S. littoralis on tomato leaves. Additionally, several histopathological and biochemical features of the some synthesized compounds under laboratory circumstances were also examined.

更新日期：2024-05-11

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南