BackgroundMalondialdehyde–acetaldehyde (MAA) adducts lead to generation of anti‐MAA autoantibodies and have been independently identified in inflamed periodontal and rheumatoid arthritis (RA) tissues. This study evaluates serum samples from RA cases and osteoarthritis (OA) controls to quantify associations between periodontal clinical measures, alveolar bone loss (ABL), and anti‐Porphyromonas gingivalis, anti‐Prevotella intermedia, and anti‐Fusobacterium nucleatum antibody concentrations with anti‐MAA antibody concentrations.MethodsParticipants (n = 284 RA cases, n = 330 OA controls) underwent periodontal clinical assessments and ABL measurements. Serum immunoglobulin (Ig) A, IgG, and IgM anti‐MAA and serum IgG antibacterial antibody concentrations were quantified by enzyme‐linked immunosorbent assay (ELISA). Analyses utilized simple linear regression and multivariable adjusted models.ResultsNo significant associations of periodontal clinical measures with serum anti‐MAA were found. Moderate (p = 0.038 and p = 0.036, respectively) and high ABL (p = 0.012 and p = 0.014, respectively) in RA cases (but not in OA) were positively associated with IgG and IgM anti‐MAA. Anti‐P. gingivalis and anti‐P. intermedia antibody concentrations were positively associated with IgA (p = 0.001 for both), IgG (p = 0.007 and p = 0.034, respectively), and IgM anti‐MAA antibody concentrations (p < 0.001 and p = 0.020, respectively), while anti‐F. nucleatum was positively associated with IgG anti‐MAA (p = 0.042), findings that were similar across groups.ConclusionsA positive association was demonstrated between ABL and serum IgG and IgM anti‐MAA antibody concentrations that was unique to RA and not observed in OA. Serum anti‐P. gingivalis, anti‐P. intermedia, and anti‐F. nucleatum antibody concentrations displayed significant associations with anti‐MAA antibody in both groups. These findings suggest MAA may play a role in the interrelationship between the periodontium and RA.

中文翻译：

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类风湿性关节炎牙周炎与血清抗丙二醛-乙醛抗体浓度之间的关联：一项病例对照研究


背景丙二醛-乙醛 （MAA） 加合物可导致抗 MAA 自身抗体的产生，并已在发炎的牙周和类风湿性关节炎 （RA） 组织中独立鉴定。本研究评估了来自 RA 病例和骨关节炎 （OA） 对照的血清样本，以量化牙周临床测量、牙槽骨质流失 （ABL） 和抗牙龈卟啉单胞菌、抗中间体普雷沃氏菌和抗核梭杆菌抗体浓度与抗 MAA 抗体浓度之间的关联。方法参与者 （n = 284 例 RA，n = 330 例 OA 对照） 接受了牙周临床评估和 ABL 测量。通过酶联免疫吸附测定 （ELISA） 定量血清免疫球蛋白 （Ig） A、IgG 和 IgM 抗 MAA 以及血清 IgG 抗菌抗体浓度。分析利用简单的线性回归和多变量调整模型。结果未发现牙周临床测量与血清抗 MAA 的显著关联。RA 病例中度 （分别为 p = 0.038 和 p = 0.036） 和高 ABL （分别为 p = 0.012 和 p = 0.014） （但在 OA 中未） 与 IgG 和 IgM 抗 MAA 呈正相关。抗牙龈卟啉假单胞菌和抗中间假单胞菌抗体浓度与 IgA （两者的 p = 0.001）、IgG （分别为 p = 0.007 和 p = 0.034） 和 IgM 抗 MAA 抗体浓度 （分别为 p < 0.001 和 p = 0.020） 呈正相关，而抗 F. nucleatum 与 IgG 抗 MAA 呈正相关 （p = 0.042），各组之间的发现相似。结论 ABL 与血清 IgG 和 IgM 抗 MAA 抗体浓度之间存在正相关，这是 RA 独有的，在 OA 中未观察到。血清抗牙龈卟啉单胞菌、抗中间假单胞菌和抗 F。 两组核酸抗体浓度均与抗 MAA 抗体显著相关。这些发现表明 MAA 可能在牙周组织和 RA 之间的相互关系中发挥作用。