Cancer-targeted therapies that inhibit oncogenic signaling often lead to resistance and recurrence. In a recent study, propose activating oncogenic pathways and inducing replication stress, resulting in cell death and tumor-suppressive mechanisms in colorectal cancer (CRC). This approach could spark a new wave of target discovery, and drug development and repurposing against cancer.

中文翻译：

---

增强致癌信号以杀死癌细胞


抑制致癌信号传导的癌症靶向治疗通常会导致耐药性和复发。在最近的一项研究中，提出激活致癌途径并诱导复制应激，从而导致结直肠癌 (CRC) 的细胞死亡和肿瘤抑制机制。这种方法可能会引发新一波的靶标发现、药物开发和癌症再利用浪潮。