Cancer cachexia is a multifactorial metabolic syndrome characterized by systemic inflammation and ongoing skeletal muscle loss resulting in weakness, poor quality of life, and decreased survival. Whereas lipid accumulation in skeletal muscle is associated with cancer cachexia as well as the prognosis of cancer patients, surprisingly little is known about the nature of the lipids that accumulate in the muscle during cachexia, and whether this is related to inflammation. We aimed to identify the types and distributions of intramyocellular lipids in patients with and without cancer cachexia.

中文翻译：

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人胰腺癌恶病质中炎症相关的肌细胞内脂质变化


癌症恶病质是一种多因素代谢综合征，其特征是全身炎症和持续的骨骼肌损失，导致虚弱、生活质量差和生存率下降。尽管骨骼肌中的脂质积累与癌症恶病质以及癌症患者的预后有关，但令人惊讶的是，人们对恶病质期间肌肉中积累的脂质的性质以及这是否与炎症有关知之甚少。我们的目的是确定患有和不患有癌症恶病质的患者肌细胞内脂质的类型和分布。