Ideas Behind the Tryptophan-Mediated Petasis Reaction (TMPR) Concept for Peptide Stapling,ChemMedChem

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Ideas Behind the Tryptophan-Mediated Petasis Reaction (TMPR) Concept for Peptide Stapling
ChemMedChem ( IF 3.6 ) Pub Date : 2024-05-10 , DOI: 10.1002/cmdc.202400148
Sona Krajcovicova _{1,

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Affiliation

This Concept review explores the pioneering role of the Petasis multicomponent reaction in peptide stapling and labelling and the use of the tryptophan indole core in peptide functionalisation. TMPR bridges the Petasis reaction and tryptophan integration, offering a novel approach to synthetic strategies in peptides. It focuses on key research papers that guided and helped to develop the idea behind this concept.

中文翻译：

色氨酸介导的 Petasis 反应 (TMPR) 肽装订概念背后的想法

本概念综述探讨了 Petasis 多组分反应在肽装订和标记中的开创性作用以及色氨酸吲哚核心在肽功能化中的使用。 TMPR 连接了 Petasis 反应和色氨酸整合，为肽合成策略提供了一种新方法。它重点关注指导和帮助发展这一概念背后的想法的关键研究论文。

更新日期：2024-05-10

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