Synthesis of Stereodefined Polysubstituted Bicyclo[1.1.0]butanes,Journal of the American Chemical Society

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Synthesis of Stereodefined Polysubstituted Bicyclo[1.1.0]butanes
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2024-05-09 , DOI: 10.1021/jacs.4c04438
Rahul Suresh ₁ , Noam Orbach ₁ , Ilan Marek ₁

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We report a highly diastereoselective synthesis of polysubstituted bicyclobutanes possessing up to three stereodefined quaternary centers and five substituents. Our strategy involves a diastereoselective carbometalation of cyclopropenes followed by a cyclization to furnish the bicyclobutane ring system. This straightforward approach allows for the incorporation of a diverse range of substituents and functional groups, notably without the need for electron-withdrawing functionalities.

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