Immune checkpoint molecules in solid organ transplantation: A promising way to prevent rejection,Immunology Letters

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Immune checkpoint molecules in solid organ transplantation: A promising way to prevent rejection
Immunology Letters ( IF 3.3 ) Pub Date : 2024-04-25 , DOI: 10.1016/j.imlet.2024.106860
Ilaria Righi ₁ , Daria Trabattoni ₂ , Lorenzo Rosso ₃ , Valentina Vaira ₄ , Mario Clerici ₅

Affiliation

Immune checkpoint (IC) molecules modulate immune responses upon antigen presentation; the interaction between different IC molecules will result in the stimulation or, rather, the thwarting of such responses. Tumor cells express increased amounts of inhibitory IC molecules in an attempt to evade immune responses; therapeutic agents have been developed that bind inhibitory IC molecules, restoring tumor-directed immune responses and changing the prognosis of a number of cancers. Stimulation of inhibitory IC molecules could be beneficial in preventing rejection in the setting of solid organ transplantation (SOT), and as well as results obtained in animal models show this to indeed to be the case. With the exception of belatacept, a monoclonal antibody (mAb) in which an IgG Fc fragment is linked to the extracellular domain of CTLA-4, this has not yet translated into the generation of novel therapeutic approaches to prevent SOT rejection. We provide a review of state-of-the art knowledge on the role played by IC molecules in transplantation, confident that innovative research will lead to new avenues to manage rejection in solid organ transplant.

中文翻译：

实体器官移植中的免疫检查点分子：预防排斥反应的一种有前途的方法

免疫检查点 (IC) 分子在抗原呈递时调节免疫反应；不同IC分子之间的相互作用将导致这种反应的刺激，或者更确切地说，阻碍。肿瘤细胞表达增加量的抑制性 IC 分子，试图逃避免疫反应；已经开发出结合抑制性 IC 分子的治疗剂，恢复肿瘤导向的免疫反应并改变许多癌症的预后。刺激抑制性 IC 分子可能有助于预防实体器官移植 (SOT) 中的排斥反应，动物模型中获得的结果表明情况确实如此。除了belatacept（一种单克隆抗体（mAb），其中 IgG Fc 片段与 CTLA-4 的细胞外结构域连接）外，该药物尚未转化为预防 SOT 排斥的新治疗方法的产生。我们对 IC 分子在移植中所发挥的作用的最新知识进行了回顾，相信创新研究将带来管理实体器官移植排斥的新途径。

更新日期：2024-04-25

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