While the toxicity of pollutants has been rather well explored in simple laboratory conditions, there is little knowledge on their real toxicity in natural environments and living organisms because pollutants are often interacting and trapped into organic matter. Because of these interactions, their real concentrations can also be underestimated. Here we studied the nature, intensity, and strength of the interactions between bisphenol A and nano-sized natural organic matter. The bioavailability and toxicity of the complexed bisphenol A were tested with human colon adenocarcinoma cell lines. Results show that that interaction of bisphenol A with organic matter reduces bisphenol A cytotoxicity. Moreover, the bisphenol A-organic matter interaction is weak in the first hour then very stable after 24 h. Once formed, the bisphenol A-organic matter complex escapes detection and, as a consequence, the levels of pollutants in organic-rich media is most probably underestimated. The mechanism of interaction involves hydrophobic and π-stacking forces inside the core of nano-sized organic matter.

虽然污染物的毒性已在简单的实验室条件下得到了相当好的研究，但人们对它们在自然环境和生物体中的真正毒性知之甚少，因为污染物经常相互作用并被困在有机物中。由于这些相互作用，它们的真实浓度也可能被低估。在这里，我们研究了双酚 A 和纳米级天然有机物之间相互作用的性质、强度和强度。用人结肠腺癌细胞系测试了复合双酚 A 的生物利用度和毒性。结果表明，双酚A与有机物的相互作用降低了双酚A的细胞毒性。此外，双酚A-有机物相互作用在第一小时内较弱，24小时后非常稳定。一旦形成，双酚A-有机物复合物就无法被检测到，因此，富含有机物的介质中的污染物水平很可能被低估。相互作用的机制涉及纳米有机物核心内部的疏水力和π堆积力。