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Nanoparticle-neutrophils interactions for autoimmune regulation
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-04-23 , DOI: 10.1016/j.addr.2024.115316
Daniel Kupor 1 , Michael L Felder 1 , Shivanie Kodikalla 2 , Xueqi Chu 1 , Omolola Eniola-Adefeso 3
Affiliation  

Neutrophils play an essential role as ‘first responders’ in the immune response, necessitating many immune-modulating capabilities. Chronic, unresolved inflammation is heavily implicated in the progression and tissue-degrading effects of autoimmune disease. Neutrophils modulate disease pathogenesis by interacting with the inflammatory and autoreactive cells through effector functions, including signaling, degranulation, and neutrophil extracellular traps (NETs) release. Since the current gold standard systemic glucocorticoid administration has many drawbacks and side effects, targeting neutrophils in autoimmunity provides a new approach to developing therapeutics. Nanoparticles enable targeting of specific cell types and controlled release of a loaded drug cargo. Thus, leveraging nanoparticle properties and interactions with neutrophils provides an exciting new direction toward novel therapies for autoimmune diseases. Additionally, recent work has utilized neutrophil properties to design novel targeted particles for delivery into previously inaccessible areas. Here, we outline nanoparticle-based strategies to modulate neutrophil activity in autoimmunity, including various nanoparticle formulations and neutrophil-derived targeting.

中文翻译:


纳米颗粒-中性粒细胞相互作用用于自身免疫调节



中性粒细胞在免疫反应中作为“第一反应者”发挥着重要作用,需要许多免疫调节能力。慢性、未解决的炎症与自身免疫性疾病的进展和组织降解作用密切相关。中性粒细胞通过效应器功能(包括信号传导、脱颗粒和中性粒细胞胞外陷阱 (NET) 释放)与炎症细胞和自身反应细胞相互作用,从而调节疾病发病机制。由于目前的金标准全身性糖皮质激素给药有许多缺点和副作用,因此针对自身免疫中的中性粒细胞提供了开发治疗方法的新方法。纳米颗粒能够靶向特定细胞类型并控制负载药物的释放。因此,利用纳米颗粒的特性以及与中性粒细胞的相互作用为自身免疫性疾病的新疗法提供了令人兴奋的新方向。此外,最近的工作还利用中性粒细胞的特性来设计新颖的靶向颗粒,以将其输送到以前无法到达的区域。在这里,我们概述了基于纳米颗粒的策略来调节自身免疫中的中性粒细胞活性,包括各种纳米颗粒制剂和中性粒细胞衍生的靶向。
更新日期:2024-04-23
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