Researchers have studied the risk factors for epilepsy recurrence among patients who withdraw from antiseizure medication (ASM). These studies aimed to determine the optimal time for ASM withdrawal. EEG findings are one of the risk factors that has been studied. However, it remains unclear whether abnormal pretreatment EEG findings are a risk factor for recurrence after ASM withdrawal. We performed this meta-analysis to clarify this issue. We retrieved literature from the PubMed and Embase databases, and used the NewcastleOttawa Scale to evaluate the methodological quality of the included studies. RevMan 5.3 software was used to analyse the data. In total,710 articles were retrieved from the databases. Ultimately, after screening, 11 articles involving 1686 patients with epilepsy were included. Compared with that for a normal EEG, the odds ratio (OR) for an abnormal EEG was 1.10 (P=0.50), with an I value of 32% (P=0.15). Subgroup analysis revealed that the children-to-adolescents subgroup had an OR of 1.21 (P=0.27), and the children-to-adults subgroup had an OR of 0.64 (P=0.14) for an abnormal EEG. A separate subgroup analysis revealed that the focal epilepsy subgroup had an OR of 1.30 (P=0.37), and the generalized epilepsy and focal epilepsy subgroup had an OR of 1.07 (P=0.67) for an abnormal EEG. The risk of epilepsy recurrence is not related to pretreatment EEG findings, regardless of age or epilepsy classification. The associations of pre- and posttreatment EEG alterations with epilepsy recurrence are controversial. Due to the limitations of our article, further research is needed.

中文翻译：

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治疗前脑电图异常与癫痫复发关系的Meta分析


研究人员研究了停用抗癫痫药物（ASM）的患者癫痫复发的危险因素。这些研究旨在确定 ASM 退出的最佳时间。脑电图结果是已研究的危险因素之一。然而，目前尚不清楚治疗前异常脑电图结果是否是 ASM 停药后复发的危险因素。我们进行了荟萃分析来澄清这个问题。我们从 PubMed 和 Embase 数据库中检索文献，并使用 NewcastleOttawa Scale 来评估纳入研究的方法学质量。 RevMan 5.3软件用于分析数据。总共从数据库中检索到 710 篇文章。最终，经过筛选，纳入11篇文章，涉及1686名癫痫患者。与正常脑电图相比，异常脑电图的优势比（OR）为1.10（P=0.50），I值为32%（P=0.15）。亚组分析显示，儿童到青少年亚组脑电图异常的 OR 为 1.21（P=0.27），儿童到成人亚组的 OR 为 0.64（P=0.14）。单独的亚组分析显示，对于异常脑电图，局灶性癫痫亚组的 OR 为 1.30（P=0.37），全身性癫痫和局灶性癫痫亚组的 OR 为 1.07（P=0.67）。无论年龄或癫痫分类如何，癫痫复发的风险与治疗前脑电图结果无关。治疗前和治疗后脑电图改变与癫痫复发的关系存在争议。由于我们文章的局限性，还需要进一步研究。