Endothelial cell (EC) metabolism plays a crucial role in the process of angiogenesis. Intrinsic metabolic events such as glycolysis, fatty acid oxidation, and glutamine metabolism, support secure vascular migration and proliferation, energy and biomass production, as well as redox homeostasis maintenance during vessel formation. Nevertheless, perturbation of EC metabolism instigates vascular dysregulation-associated diseases, especially cancer. In this review, we aim to discuss the metabolic regulation of angiogenesis by EC metabolites and metabolic enzymes, as well as prospect the possible therapeutic opportunities and strategies targeting EC metabolism. In this work, we discuss various aspects of EC metabolism considering normal and diseased vasculature. Of relevance, we highlight that the implications of EC metabolism-targeted intervention (chiefly by metabolic enzymes or metabolites) could be harnessed in orchestrating a spectrum of pathological angiogenesis-associated diseases.

中文翻译：

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代谢重编程和血管生成干预

内皮细胞（EC）代谢在血管生成过程中起着至关重要的作用。糖酵解、脂肪酸氧化和谷氨酰胺代谢等内在代谢事件支持安全的血管迁移和增殖、能量和生物量的产生，以及血管形成过程中氧化还原稳态的维持。然而，EC 代谢的扰动会引发血管失调相关疾病，尤其是癌症。在这篇综述中，我们旨在讨论EC代谢物和代谢酶对血管生成的代谢调节，并展望针对EC代谢的可能的治疗机会和策略。在这项工作中，我们讨论了考虑正常和患病脉管系统的 EC 代谢的各个方面。相关的是，我们强调 EC 代谢靶向干预（主要通过代谢酶或代谢物）的影响可用于协调一系列病理性血管生成相关疾病。