Bioprinting-Assisted Tissue Assembly for Structural and Functional Modulation of Engineered Heart Tissue Mimicking Left Ventricular Myocardial Fiber Orientation,Advanced Materials

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Bioprinting-Assisted Tissue Assembly for Structural and Functional Modulation of Engineered Heart Tissue Mimicking Left Ventricular Myocardial Fiber Orientation
Advanced Materials ( IF 27.4 ) Pub Date : 2024-05-08 , DOI: 10.1002/adma.202400364
Dong Gyu Hwang ₁ , Hwanyong Choi ₂ , Uijung Yong ₃ , Donghwan Kim ₄ , Wonok Kang ₅ , Sung-Min Park _{2,

4,

5,

6} , Jinah Jang _{1,

2,

3,

4,

5,

7}

Affiliation

Left ventricular twist is influenced by the unique oriented structure of myocardial fibers. Replicating this intricate structural-functional relationship in an in vitro heart model remains challenging, mainly due to the difficulties in achieving a complex structure with synchrony between layers. This study introduces a novel approach through the utilization of bioprinting-assisted tissue assembly (BATA)—a synergistic integration of bioprinting and tissue assembly strategies. By flexibly manufacturing tissue modules and assembly platforms, BATA can create structures that traditional methods find difficult to achieve. This approach integrates engineered heart tissue (EHT) modules, each with intrinsic functional and structural characteristics, into a layered, multi-oriented tissue in a controlled manner. EHTs assembled in different orientations exhibit various contractile forces and electrical signal patterns. The BATA is capable of constructing complex myocardial fiber orientations within a chamber-like structure (MoCha). MoCha replicates the native cardiac architecture by exhibiting three layers and three alignment directions, and it reproduces the left ventricular twist by exhibiting synchronized contraction between layers and mimicking the native cardiac architecture. The potential of BATA extends to engineering tissues capable of constructing and functioning as complete organs on a large scale. This advancement holds the promise of realizing future organ-on-demand technology.

中文翻译：

生物打印辅助组织组装，用于模拟左心室心肌纤维取向的工程心脏组织的结构和功能调节

左心室扭转受到心肌纤维独特的定向结构的影响。在体外心脏模型中复制这种复杂的结构功能关系仍然具有挑战性，这主要是因为难以实现层间同步的复杂结构。这项研究引入了一种利用生物打印辅助组织组装（BATA）的新方法——生物打印和组织组装策略的协同整合。通过灵活制造组织模块和组装平台，BATA 可以创建传统方法难以实现的结构。这种方法将工程心脏组织 (EHT) 模块（每个模块都具有内在的功能和结构特征）以受控方式集成到分层、多方向的组织中。以不同方向组装的 EHT 表现出不同的收缩力和电信号模式。 BATA 能够在室状结构 (MoCha) 内构建复杂的心肌纤维方向。 MoCha 通过展示三层和三个对齐方向来复制原生心脏结构，并通过展示各层之间的同步收缩和模仿原生心脏结构来再现左心室扭转。 BATA 的潜力延伸到能够大规模构建和发挥完整器官功能的工程组织。这一进步有望实现未来的器官按需技术。

更新日期：2024-05-08

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