<br>手性光学活性铜簇作为赖氨酸对映选择性检测的平台,Chirality

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手性光学活性铜簇作为赖氨酸对映选择性检测的平台
Chirality ( IF 2.8 ) Pub Date : 2024-05-08 , DOI: 10.1002/chir.23670
Camelia Dutta ₁ , Ragul Vivaz Nataraajan ₁ , Jatish Kumar ₁

Affiliation

多年来，金属团簇因其迷人的光学特性而引起了广泛的研究关注。由于其引人注目的光物理特性，这些材料作为不同领域各种应用的潜在候选者而引起人们的关注，包括疾病检测、生物传感、化学传感和光捕获材料的制造。目前，越来越多的研究关注集群在生物医学研究中的使用，无论是作为生物检测平台还是作为生物成像剂。特别令人感兴趣的是手性簇，由于其光学活性，它可以选择性地与手性生物分子相互作用。在此，我们展示了使用一对手性光学活性铜簇对赖氨酸（一种具有广泛生物相关性的氨基酸）进行对映选择性检测。同时采用两种技术来检测不同浓度的赖氨酸。圆二色性是检测低浓度赖氨酸的有效工具，而发光则有效地用作高浓度分析物的检测方法。簇和赖氨酸的联合电子影响导致在特定波长下出现增强的对映选择性棉花效应。

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Chiroptically active copper clusters as platform for enantioselective detection of lysine

Metal clusters have drawn considerable research attention over the years due to their fascinating optical properties. Owing to their appealing photophysical characteristics, these materials have drawn attention as potential candidates for various application in diverse fields, including disease detection, biosensing, chemical sensing, and the fabrication of light‐harvesting materials. Presently, there is an increasing research focus on the use of clusters in biomedical research, both as biodetection platform and as bioimaging agents. Of special interest are chiral clusters, which can selectively interact with chiral biomolecules owing to their optical activity. Herein, we showcase the use of a pair of chiroptically active copper clusters for the enantioselective detection of lysine, an amino acid of vast biological relevance. Two techniques are concurrently employed for the detection of lysine at varying concentrations. Circular dichroism serves as a potent tool for detecting lysine at low concentrations, whereas luminescence is effectively employed as a detection method for high analyte concentrations. The combined electronic impact of clusters and lysine resulted in the emergence of an enhanced enantioselective Cotton effect at specific wavelength.

更新日期：2024-05-08

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