As a new form of regulated cell death, ferroptosis has unraveled the unsolicited theory of intrinsic apoptosis resistance by cancer cells. The molecular mechanism of ferroptosis depends on the induction of oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage the structural integrity of cells. Due to their high loading and structural tunability, nanocarriers can escort the delivery of ferro-therapeutics to the desired site through enhanced permeation or retention effect or by active targeting. This review shed light on the necessity of iron in cancer cell growth and the fascinating features of ferroptosis in regulating the cell cycle and metastasis. Additionally, we discussed the effect of ferroptosis-mediated therapy using nanoplatforms and their chemical basis in overcoming the barriers to cancer therapy.

作为一种新的受调节细胞死亡形式，铁死亡揭示了癌细胞自发抵抗固有凋亡的理论。铁死亡的分子机制取决于通过过量的活性氧积累和谷胱甘肽消耗诱导氧化应激，从而损害细胞的结构完整性。由于其高负载量和结构可调性，纳米载体可以通过增强的渗透或保留效应或通过主动靶向，护送铁治疗药物递送至所需位点。这篇综述阐明了铁在癌细胞生长中的必要性以及铁死亡在调节细胞周期和转移中的迷人特征。此外，我们还讨论了使用纳米平台进行铁死亡介导的治疗的效果及其在克服癌症治疗障碍方面的化学基础。