The immune interactions of gut glycans and microbiota in health and disease,Molecular Microbiology

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The immune interactions of gut glycans and microbiota in health and disease
Molecular Microbiology ( IF 2.6 ) Pub Date : 2024-05-04 , DOI: 10.1111/mmi.15267
Mahmut Demirturk ₁ , Mukaddes Sena Cinar ₁ , Fikri Y Avci ₁

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The human digestive system harbors a vast diversity of commensal bacteria and maintains a symbiotic relationship with them. However, imbalances in the gut microbiota accompany various diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancers (CRCs), which significantly impact the well-being of populations globally. Glycosylation of the mucus layer is a crucial factor that plays a critical role in maintaining the homeostatic environment in the gut. This review delves into how the gut microbiota, immune cells, and gut mucus layer work together to establish a balanced gut environment. Specifically, the role of glycosylation in regulating immune cell responses and mucus metabolism in this process is examined.

中文翻译：

肠道聚糖和微生物群在健康和疾病中的免疫相互作用

人体消化系统拥有种类繁多的共生细菌，并与它们保持共生关系。然而，肠道微生物群的失衡伴随着各种疾病，例如炎症性肠病（IBD）和结直肠癌（CRC），这些疾病会严重影响全球人口的福祉。粘液层的糖基化是一个关键因素，在维持肠道中的稳态环境中起着关键作用。这篇综述深入探讨了肠道微生物群、免疫细胞和肠道粘液层如何协同工作以建立平衡的肠道环境。具体来说，研究了糖基化在此过程中调节免疫细胞反应和粘液代谢中的作用。

更新日期：2024-05-04

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